Expert Opinion on Therapeutic Patents. From Wikipedia, the free encyclopedia. Fitting the model term Y 3 into polynomial quadric model, they were found to be significant with an F value The disintegration time of the wafer was kept at 0. Buccal delivery of fluorescein isothiocyanate-dextran and the peptide drug buserelin with glycodeoxycholate as an absorption enhancer in pigs. 
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In this case, ABA 2and B 2 were significant. I want this software for 1 month. RSM provides an estimate for the value of responses for every possible combination of the factors by varying the values of all factors in parallel, making it possible to comprehend a multi-dimensional surface triwl non-linear shapes.
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The depression of the endothermic peak in drug-loaded wafer suggested that LOR could be present in an amorphous form in the matrix of the wafer, and its behaviour would be expected to amend the solubility of the drug in water, resulting in better bioavailability. Representative graph of the in vitro bioadhesion test FNA 6. Replika Press Private Limited; Contour plot showing the optimization procedure depending on numerical method.
National Center for Biotechnology InformationU. The wafer size required for dose delivery 3. The in vitro bioadhesion properties of the pharmaceutical wafers were assessed on bovine buccal mucosa as a model membrane, using a TAXT2i texture analyzer.
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Swelling Index Study [ 1415 ] Three wafers surface area: A calculated amount of LOR dissolved in aliquot of ethanol was added in the vortex of the vigorously stirred suspension of the plasticized aqueous polymeric gel. Table 3 Response parameter for Loratadine-loaded buccoadhesive pharmaceutical wafers prepared as per 3 2 factorial design.
The objective of this work encompasses the application of the response surface approach in the development of buccoadhesive pharmaceutical wafers of Loratadine LOR.
The pharmaceutical wafers hold potential advantages like rapid disintegration, no swallowing or chewing, no coadministration of water, accurate dosing compared to liquid products, great safety, and efficacy along with patient compliance. The American Journal of Medicine.
The pH of the wafers was within the acceptable range and desgn sufficient mechanical strength rendering it nonirritant to the mucosal surface and ensuring flexibility of expegt wafers, respectively. Investigation of Drug-Excipient Interactions 2. Thank you for rating the program! The main effects A and B postulate the average result of changing one factor at a time from its low to high value.
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Optimization and validation of modulated release formulation of ranitidine HCl by eesign surface methodology. Optimization of sustained-release propranolol dosage form using factorial design and response surface methodology.
Majority of the drugs prescribed to patients are conventional tablets and capsules, 8.0.71. less attention has been paid to patients experiencing difficulty in swallowing dysphagia [ 1 ]. Vandervoort J, Ludwig A. Published online May For pure LOR, a sharp endotherm was recorded at expret The disintegration time of the wafer increased proportionately with the fraction of sodium alginate and lactose monohydrate.
International Journal of Pharmaceutics. Optimization An optimum setting for the formulation was generated by the numerical optimization technique following desirability approach.
This is due to the fact that the two important variables, that is, bioadhesiveness imparted by the incorporation of a bioadhesive polymer and texture of wafer dosage form due to the filler, shall contribute effect on the nature and performance of the bioadhesive pharmaceutical wafers. Radial swelling was calculated from the following equation:.
Buccal bioadhesive delivery system of 5-fluorouracil: The measurement was made in triplicate with the standard deviation as a measure of variation. The combined effect of factors A and B could further be elucidated with the help of response surface and contour plots Figures 8 a and 8 b.
The value of correlation coefficient r 2 was found to be 0.
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